A new variant of HIV is dicovered in Cuba. It is a recombinant form of HIV. It should be noted that HIV has various form - or technically various strains. A person who engages in unprotected sex with many persons infected with HIV, he or she may contract multiple strains of HIV. Then these various forms
of HIV combine to form a new variant in the body of the person.
How does HIV develop to AIDS?
HIV attaches itself to co-receptors - proteins on the membranes of cells - before the virus is able to penetrate the cell. The first co-receptor that HIV anchors to is known as CCR5. Then, after a number of years of normal health, the virus switches to the anchor point CXCR4, which results in a faster progression to AIDS.
But the new form of HIV identified in Cuba moves immediately to CXCR4 shortly after infection, reducing the healthy phase and initiating the progression to AIDS.
An international team of researchers compared the blood of 73 recently-infected patients with this recombinant form of HIV - of whom 52 had been diagnosed with AIDS - with blood from 22 patients who had progressed to AIDS after the normal "healthy" period of infection with HIV.
The patients with the recombinant HIV were found to have abnormally high doses of the virus and defensive molecules called RANTES. This RANTES, is part of immune response. It binds with CCR5, just as HIV immediately after infection
Because RANTES is present at higher concentrations in these patients than normal, it suggests that most of the CCR5 proteins were unavailable as anchor points for HIV. Therefore, the recombinant HIV would have to bypass its usual anchor point, heading straight to CXCR4 instead
Culled from Medical News Today
of HIV combine to form a new variant in the body of the person.
How does HIV develop to AIDS?
HIV attaches itself to co-receptors - proteins on the membranes of cells - before the virus is able to penetrate the cell. The first co-receptor that HIV anchors to is known as CCR5. Then, after a number of years of normal health, the virus switches to the anchor point CXCR4, which results in a faster progression to AIDS.
But the new form of HIV identified in Cuba moves immediately to CXCR4 shortly after infection, reducing the healthy phase and initiating the progression to AIDS.
An international team of researchers compared the blood of 73 recently-infected patients with this recombinant form of HIV - of whom 52 had been diagnosed with AIDS - with blood from 22 patients who had progressed to AIDS after the normal "healthy" period of infection with HIV.
The patients with the recombinant HIV were found to have abnormally high doses of the virus and defensive molecules called RANTES. This RANTES, is part of immune response. It binds with CCR5, just as HIV immediately after infection
Because RANTES is present at higher concentrations in these patients than normal, it suggests that most of the CCR5 proteins were unavailable as anchor points for HIV. Therefore, the recombinant HIV would have to bypass its usual anchor point, heading straight to CXCR4 instead
Culled from Medical News Today
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