According to WHO, a child dies every minute from malaria. This deadly disease killed up to 600,000 people in 2013 and most of them are children in Africa.
New statistics shows that at least half of the population of people in malaria prone areas have access to insecticide treated mosquito nets.
It is known that a first malaria bite to a child could be deadly. But after surviving this stage, further bites from mosquitoes helps the child to develop immunity
. In 2013, there were an estimated 198 million malaria cases worldwide according to World Health Organization.
Although malaria has 20 available vaccine candidates, none have been approved for use. A University of Michigan conducted a research that showed that combining malaria vaccine with malaria net could be worse
"The joint use of bed nets and vaccines will not always lead to consistent increases in the efficacy of malaria control. In some cases, the use of vaccines and bed nets may actually make the situation worse," said Mercedes Pascual, a professor in the U-M Department of Ecology and Evolutionary Biology.
"Specifically, our study suggests that the combination of some malaria vaccines with bed nets can lead to increased morbidity and mortality in older age classes."
The malaria vaccines which are not yet approved fall into three categories:
PEVs(Preerythrocytic vaccines)- This class reduce the possibility of getting infested after a malaria bite
BSVs(Blood-stage vaccines)- They act by reducing the number of deaths and severity of malaria. They don't protect from infection.
TBVs( Transmission-block Vaccines) They don't protect vaccinated individuals against infection or illness. But they prevent mosquitoes from spreading the disease to others and thus they are called altruistic vaccines.
Pascual and her colleagues found that the combination of treated bed nets and TBV vaccines achieves the most efficient control, resulting in fewer cases of malaria while increasing the probability of eliminating the disease.
"Ironically, the vaccines that work best with bed nets are the ones that do not protect the vaccinated host -- the bed net does that -- but instead block transmission of malaria in mosquitoes that have found an opportunity to bite vaccinated hosts," Artzy-Randrup said.
In contrast, both BSV and PEV malaria vaccines, when combined with bed nets, actually increased the number of malaria cases seen in the modeling study.
Interactions between the bed nets and those vaccines reduced levels of natural immunity in the population, increasing death and have led to rejection of several vaccines for malaria.
A breakthrough research has also shown that Vitamin A reduces malaria in children
It is known that a first malaria bite to a child could be deadly. But after surviving this stage, further bites from mosquitoes helps the child to develop immunity
. In 2013, there were an estimated 198 million malaria cases worldwide according to World Health Organization.
Although malaria has 20 available vaccine candidates, none have been approved for use. A University of Michigan conducted a research that showed that combining malaria vaccine with malaria net could be worse
"The joint use of bed nets and vaccines will not always lead to consistent increases in the efficacy of malaria control. In some cases, the use of vaccines and bed nets may actually make the situation worse," said Mercedes Pascual, a professor in the U-M Department of Ecology and Evolutionary Biology.
"Specifically, our study suggests that the combination of some malaria vaccines with bed nets can lead to increased morbidity and mortality in older age classes."
The malaria vaccines which are not yet approved fall into three categories:
PEVs(Preerythrocytic vaccines)- This class reduce the possibility of getting infested after a malaria bite
BSVs(Blood-stage vaccines)- They act by reducing the number of deaths and severity of malaria. They don't protect from infection.
TBVs( Transmission-block Vaccines) They don't protect vaccinated individuals against infection or illness. But they prevent mosquitoes from spreading the disease to others and thus they are called altruistic vaccines.
Pascual and her colleagues found that the combination of treated bed nets and TBV vaccines achieves the most efficient control, resulting in fewer cases of malaria while increasing the probability of eliminating the disease.
"Ironically, the vaccines that work best with bed nets are the ones that do not protect the vaccinated host -- the bed net does that -- but instead block transmission of malaria in mosquitoes that have found an opportunity to bite vaccinated hosts," Artzy-Randrup said.
In contrast, both BSV and PEV malaria vaccines, when combined with bed nets, actually increased the number of malaria cases seen in the modeling study.
Interactions between the bed nets and those vaccines reduced levels of natural immunity in the population, increasing death and have led to rejection of several vaccines for malaria.
A breakthrough research has also shown that Vitamin A reduces malaria in children
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